Peter Attia’s Supplement Framework – Questions to ask before adding supplements

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During Peter’s AMA #69 he described a set of questions, or framework, for how to think about supplements one might take.

First, let’s look at it in diagram form:

Now let’s look at the framework in text form:

1. Deficiency vs. Enhancement: Are you correcting a deficiency or seeking supranormal levels?
2. Goal: Are you targeting lifespan, healthspan, or both?
3. Mechanism of Benefit:

If lifespan: Is it disease-specific or broadly protective?
If healthspan: Which domain – physical performance, cognitive performance, or emotional health?

4. Trackable Biomarker: Can you measure whether you’re in the therapeutic window?
5. Mechanism of Action: Do you understand how it works? (Not required, but helpful)
6. Risk-Benefit Analysis: Consider side effects, effect magnitude, data confidence, and supplement quality (the last point is critical – quality issues in supplements are far more prevalent than in pharmaceuticals).

Roundup

Above is a useful framework for thinking about any supplements we might take.

For more on Dr Attia’s supplements, see:

• Peter Attia’s Full Supplement List

If you’ve any questions or comments, please leave them below.